Produção Científica


  1. Nagagata BA, Brito G, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Melatonin supplementation in obese mothers reduces hypothalamic inflammation and enhances thermogenesis in mice progeny. J Nutr Biochem 2024; 128: 109635 (doi: 10.1016/j.jnutbio.2024.109625)
  2. Spezani R, Marinho TS, Santos-Reis T, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide (GLP-1/Glucagon dual receptor agonist) modulates hypothalamic orexigenic and anorexigenic neuropeptides in obese mice. Peptides 2024; 173: 171138 (doi:10.1016/j.peptides.2023.171138).


  1. Ajackson M, Nagagata BA, Marcondes-de-Castro IA, Mandarim-de-Lacerda CA, Aguila MB. Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress. Life Sciences 2023;312:121253 (doi:10.1016/j.lfs.2022.121253)
  2. Azulay RD, Bravo B, Azulay V, Ronir R, Cuzzi T, Mandarim-de-Lacerda CA, Azulay M. Durability of the improvement of collagen I and III with the use of oral isotretinoin in the treatment of photoaging. Int J Dermatol 2023:e16868 (doi: 10.1111/ijd.16868)
  3. Cardoso LEM, Marinho TS, Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Treatment with semaglutide, a GLP-1 receptor agonist, improves extracellular matrix remodeling in the pancreatic islet of diet-induced obese mice. Life Sci 2023;319:121502 (doi: 10.1016/j.lfs.2023.121502)
  4. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. High-intensity interval training (treadmill) effects in myokines and endoplasmic reticulum stress of calf muscles in obese mice. Int J Morphol 2023;41:591-599 (doi: 10.4067/S0717-9502202300020059)
  5. Marcondes-de-Castro IA, Oliveira TF, Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide effect in liver and adipose tissue in obese mice. J Mol Endocrinol 2023;70(3):e220168 (doi: 10,1530/JME-22-0168)
  6. Marcondes-de-Castro IA, Reis-Barbosa PH, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. AMPK/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression. J Gastroenterol Hepatol 2023;38(7):16272 (doi: 10.1111/jgh.16272)
  7. Martins FF, Santos-Reis T. Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Hypothalamic anorexigenic signaling pathways (leptin, amylin, and proopiomelanocortin) are semaglutide (GLP-1 analog) targets in obesity control in mice. Life Sciences 2023;313:121268 (doi: 10.1016/j.lfs.2022.121268)
  8. Nagagata BA, Ajackson M, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function. J Dev Orig Health Dis 2023:1-11 (doi:10.1017/S2040174423000168)
  9. Petito-da-Silva TI, Villardi Jr FM, Penna-de-Carvalho A, Mandarim-de-Lacerda CA, Souza-Mello V, Barbosa-da-Silva S. An intestinal FXR agonist mitigates dysbiosis, intestinal tight junctions and inflammation in high-fat diet-fed mice. Mol Nut Food Res 2023; 2300148 (doi: 10.1002/mnfr.202300148)
  10. Santana-Oliveira DA, Tavares HS, Fernandes-da-Silva A, Silva-Veiga F, Casimiro-Lopes G, Lisboa PC, Mandarim-de-Lacerda CA, Souza-Mello V. Exercise (HIIT and MICT) prevents obesity by reducing gut-derived inflammatory signals to brown adipocytes in high-fat-fed mice. J Endocrinol 2023;259:2e230123 (doi: 10.1530/JOE-23-0123)
  11. Spezani R, Marinho TS, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet remodeling in cotadutide-treated obese mice. Life Sciences 2023;327:121858 (doi: 10.1016/j.lfs.2023.121858
  12. Spezani R, Marcondes-de-Castro IA, Marinho TS, Reis-Barbosa PH, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Cotadutide improves brown adipose tissue thermogenesis in obese mice. Biochem Pharmacol 2023;217:115852 (doi:10.1016/j.bcp.2023.115852).



1. Araujo N, Orlando MM, Neves M, Souza R, Mandarim-de-Lacerda CA. Evaluation of spleen function in renal transplant patients and controls by liver-spleen scanning using qualitative and quantitative methods. Int J Innov Res Med Sci (IJIRMS) 2022;7 (3): 167-172 (doi: 10.23958/ijrms/vol07-i03/1373)

2. Azevedo CR, Santana-Oliveira D, Miranda CS, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. Progressive brown adipocyte dysfunction: whitening and impaired nonshivering thermogenesis as long-term obesity complications. J Nutr Biochem 2022;105:109002 (doi: 10.1016/j.jnutbio.2022.109002)

3. Castro-de-Paiva P, Marinho TS, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease. J Nutr Biochem 2022;104:108997 (doi: 10.1016/j.jnutbio.2022.108997)

4. Cotrin JC, Souza GSM, Petito-da-Silva TI, Cardoso LEM, Souza-Mello V, Barbosa-da-Silva S. Empagliflozin Alleviates Left Ventricle Hypertrophy in High-Fat-Fed Mice by Modulating Renin Angiotensin Pathway. Journal of the Renin-Angiotensin-Aldosterone System 2022; 8861911 (doi: 10.1155/2022/8861911)

5. Hubert J, Vouhe P, Poitout D, Bagot M, Pion M, Vuitton DA, Mandarim-de-Lacerda CA, Delmas V., et al. Rapport 21-13. Formation des chirurgiens/des équipes chirurgicales à la chirurgie robot-assistée. État de la situation actuelle. Propositions d’améliorations. Bull l’Acad Nat Méd 2022;206:167-78 (doi: 10.1016/j.banm.2021.12.008)

6. Mandarim-de-Lacerda CA. The morphological challenge in determining nuclear size and shape in anatomopathological neoplasia analysis. Int J Morphol 2022;40:683-7 (doi: 10.4067/S0717-95022022000300683)

7. Marinho TS, Martins FF, Cardoso LEM, Aguila MB, Mandarim-de-Lacerda CA. Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment. Biochimie 2022;193:126-136 (doi: 10.1016/j.biochi.2021.10.017).

8. Miranda CS, Silva-Veiga FM, Santana-Oliveira DA, Fernandes-da-Silva A, Brito GC, Martins FF, Souza-Mello V. Chronic Excessive Fructose Intake Maximizes Brown Adipocyte Whitening but Causes Similar White Adipocyte Hypertrophy Than a High-Fat Diet in C57BL/6 Mice. J Am Nutr Assoc 2022; 13:1-10 (doi: 10.1080/07315724.2022.2062686).

9. Martins FF, Marinho TS, Cardoso LEM, Barbosa-da-Silva S, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Semaglutide (GLP-1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice. Cell Biochem Funct 2022:1-11 (doi: 10.1002/cbf.3751)

10. Pontes-da-Silva RM, Marinho TS, Cardoso LEM, Mandarim-de-Lacerda CA, Aguila MBObese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist.Int J Obes 2022; 46:21:29 (doi: 10.1038/s41366-021-00955-7).

11. Reis-Barbosa PH, Marcondes-de-Castro I, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice. Clin Res Hepatol Gastroenterol 2022;46(6):10192 (doi: 10.1016/j.clinre.2022.101922)

12. Reis-Barbosa PH, Marinho TS, Matsuura C, Aguila MB, Carvalho JJ, Mandarim-de-Lacerda CA. The obesity and nonalcoholic fatty liver disease mouse model revisited: liver oxidative stress, hepatocyte apoptosis, and proliferation. Acta Histochemica 2022;124(7):151937 (doi: 10.1016/j.acthis.2022.151937)

13. Santana-Oliveira DA, Fernandes-da-Silva A, Miranda CS, Martins FF, Mandarim-de-Lacerda CA, Souza-Mello V. A PPAR-alpha agonist and DPP-4 inhibitor mitigate adipocyte dysfunction in obese mice. J Mol Endocrinol 2022, 68(4):225-241 (doi: 10.1530/JME-21-0084).

14. Santana-Oliveira DA, Fernandes-da-Silva A, Martins FF, Barbosa-da-Silva S, Souza-Mello V. Metabolic pathways involved in the beneficial effects of HITT in rodent models. In: Advances in Health and Disease. Nova Science Publishers: Nova Iorque, 2022 (doi:10.52305/EYMC350).

15. Silva-Veiga FM, Miranda CS, Vasques-Monteiro IML, Souza-Tavares H, Martins FF, Daleprane JB, Souza-Mello V. Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice. World J Gastroenterol 2022, 28(17):1814-1829 (doi: 10.3748/wjg.v28.i17.1814).

16. Spezani R, Mandarim-de-Lacerda CA. The current significance and prospects for the use of dual receptor agonism GLP-1/Glucagon. Life Sciences  2022;288:120188 (doi:


      1. Aguila MB, Ornellas F, Mandarim-de-Lacerda CA. Nutritional research and fetal programming: parental nutrition influences the structure and function of the organs. Int J Morphol 2021;39:327-334 (doi: 10.4067/S0717-95022021000100327).
      2. Fernandes-da-Silva A, Miranda CS, Santana-Oliveira DA, Oliveira-Cordeiro B, Rangel-Azevedo C, Silva-Veiga FM, Martins FF, Souza-Mello V. Endoplasmic reticulum stress as the basis of obesity and metabolic diseases: focus on adipose tissue, liver, and pancreas. Eur J Nutr. 2021; 60(6):2949-2960 (doi: 10.1007/s00394-021-02542-y).
      3. Mandarim-de-Lacerda CA, Del Sol M, Vasquez B, Aguila MB. Mice as an animal model for the study of adipose tissue and obesity. Int J Morphol 2021;39:1521-1528 (doi: 10.4067/S0717-95022021000601521).
      4. Martins FF; Souza-Mello V; Carvalho JJ; Del Sol M; Aguila MB, Mandarim-de-Lacerda CA. Liver structural injury in leptin-deficient (ob/ob -/-) mice: lipogenesis, fibrogenesis, inflammation, and apoptosis.Int J Morphol 2021; 39:732-738 (doi: 10.4067/S0717-95022021000300732).
      5. Reis-Barbosa PH, De Carvalho JJ, Del Sol M, Mandarim-de-Lacerda, CA. Hepatic mitochondria in diet-induced obese mice (stereology and molecular analysis). Int J Morphol, 2021;39(2):571-576 (doi: 10.4067/S0717-95022021000200571).
      6. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Maternal swimming mitigates liver damage caused by paternal obesity.Nutrition 2021;86: 111168 (doi: 10.1016/j.nut.2021.111168).
      7. Vasques-Monteiro IML, Silva-Veiga FM, Miranda CS, de Andrade Gonçalves ÉCB, Daleprane JB, Souza-Mello V. A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice. Nutr Res 2021;91:26-35. (doi: 10.1016/j.nutres.2021.04.008).


    1. Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E. Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis. 2020; 30(1):151-161. (doi: 10.1016/j.numecd.2019.09.001).Borges CC, Bringhenti I, Aguila MB, Mandarim-de-Lacerda CA. Vitamin D restriction enhances the periovarian adipose tissue inflammation in a model of menopause. Climacteric 2020;23:99-104 (doi: 10.1080/13697137.2019.1597841).

    2. Filomeno CES, Costa-Silva M, Correa CL, Neves RH, Mandarim-de-Lacerda CA, Machado-Silva JR. The acute schistosomiasis mansoni ameliorates metabolic syndrome in the C57BL/6 mouse model. Exp Parasitol 2020; 212: 107889 (doi: 10.1016/j.exppara.2020.107889)
    3. Leite KG , Lopes-Torres EJ, Souza JGR, Neves RH, Gomes DC, Machado-Silva JR. Eurytrema coelomaticum : updated morphology of adult worms using advanced microscopy experiments. J Helminthol 2020; 94:1-9 (doi: 10.1017/S0022149X19001135)
    4. Marinho TS, Borges CC, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting benefits on alpha- and beta-cell arrangement in diet-induced obese mice pancreatic islet. J Diab Complications 2020:34:107497 (doi: 10.1016/j.jdiacomp.2019.107497)
    5. Marinho TS, Ornellas F, Aguila MB, Mandarim-de-Lacerda CA. Browning of the subcutaneous adipocytes in diet-induced obese mouse submitted to intermittent fasting. Mol Cell Endocrinol 2020;513:110872 (doi: 10.1016/j.mce.2020.110872)
    6. Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Eicosapentaenoic and docosapentaenoic acids lessen the expression of PPARγ / Cidec affecting adipogenesis in cultured 3T3-L1 adipocytes. Acta Histochemica 2020;122:151504 (doi:10.1016/j.acthis.2020.151504)
    7. Miranda CA, Silva-Veiga F, Martins FF, Rachid TL, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation counters brown adipose tissue whitening: a comparative study between high-fat and high-fructose-fed mice. Nutrition 2020; 78:110791 (doi: 10.1016/j.nut.2020.110791)
    8. Oliveira FS, Correia BRO, Marinho TS, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Souza-Mello V. Anti-steatotic linagliptin pleiotropic effects encompasses suppression of de novo lipogenesis and ER stress in high-fat-fed mice. Mol Cell Endocrinol 2020; 509: 110804 (doi: 10.1016/j.mce.2020.110804)
    9. Ornellas F, Carapeto PV, Aguila MB, Mandarim-de-Lacerda CA.Sex-linked changes and high cardiovascular risk markers in the mature progeny of father, mother, or father and mother together consuming a high-fructose diet. Nutrition 2020;71:110612 (doi: 10.1016/j.nut.2019.110612)
    10. Ornellas F., Karise I., Aguila M.B., Mandarim-de-Lacerda C.A. (2020) Pancreatic Islets of Langerhans: Adapting Cell and Molecular Biology to Changes of Metabolism. In: Faintuch J., Faintuch S. (eds) Obesity and Diabetes. Springer, Cham. (doi:10.1007/978-3-030-53370-0_13).
    11. Radighieri AR, Bentes AC, Machado BA, Franco CS, Leal CMC, Guimarães DB, Costa IO, Ramalho IA, Silva JLO, Silva JFG, Gomes RB, Cunha TF, Neves RH. Vivenciando a estensão universitária na formação dos discentes de enfermagem através de ações de educação em saúde em parasitologia: Associação entre a teoria e a prática. Ponta grossa: Athena, 2020 (DOI: 10.22533/at.ed.74520030227).
    12. Reis-Barbosa PH, Carvalho JJ, Del Sol M, Mandarim-de-Lacerda CA. Commentary on mitochondrial stereology in transmission electron microscopy. Int J Morphol 2020;38:26-29 (doi: 10.4067/S0717-95022020000100026).
    13. Rosa AP, Brito ACS, Silva BM, Filomeno CES, Paschoal IM, Bruno IMS, Maria JBM, Silva JFG, Leite KG, Bezerra LB, Lima LR, Melo T, Neves RH. Tecendo saberes: Um estudo sobre a tricomoníase no contexto escolar. Ponta grossa: Athena, 2020 (DOI: 10.22533/at.ed.75220030223).
    14. Silva-Veiga FM, Miranda CS, Martins FF, Daleprane JB, Mandarim-de-Lacerda CA, Souza-Mello V. PPAR-alpha activation and DPP-4 inhibition mitigate liver steatosis through gut-liver axis modulation in high-fructose-fed mice. J Endocrinol  2020; 247(1):11-24 (doi:10.1530/JOE-20-0139)
    15. Spezani R, Silva RR, Martins FF, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Intermittent fasting, adipokines, insulin sensitivity, and hypothalamic neuropeptides in a dietary overload with high-fat or high-fructose diet in mice. J Nutrit Biochem 2020;83:108419 (doi: 10.1016/j.jnutbio.2020.108419).
    16. Teixeira TV, Gomes SMR, Lima LR, Melo T, Leite KG, Filomeno CES, Brito ACS, Silva BM, Rosa AP, Siqueira LM, Jorge LCC, Machado-Silva JR, Neves RH. Estratégias metodológicas de Educação em Saúde na área de Parasitologia para aplicação em atividades em ambientes não formais de ensino com crianças, jovens e adultos. Ponta grossa: Athena, 2020 (DOI: 0010.22533/at.ed.0922018099).


  1. Avelar LDGA, Gava SG, Neves RH, Silva MCS, Araújo N, Tavares NC, Khal AE, Mattos ACA, Machado-Silva JR, Oliveira G, Mourão MM. Smp38 MAP Kinase Regulation in Schistosoma mansoni: Roles in Survival, Oviposition, and Protection Against Oxidative Stress. Front Immunol. 2019; Jan 24;10:21 (doi: 10.3389/fimmu.2019.00021)
  2. Bargut TCL, Martins FF, Santos LP, Aguila MB, Mandarim-de-Lacerda CA. Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice. Mol Cell Endocrinol 2019; 482:18-27 (doi: 10.1016/j.mce.2018.12.003).
  3. Borba VH, Machado-Silva JR, Le Bailly M, Iñiguez AM. Worldwide paleodistribution of capillariid parasites: Paleoparasitology, current status of phylogeny and taxonomic perspectives. PLoS One 2019; 14(4):e0216150 (doi: 10.1371/journal.pone.0216150).
  4. Brandão-Bezerra L, de Carvalho Martins JSC, de Oliveira RMF, Lopes-Torres EJ, Neves RH, Corrêa CL, Machado-Silva JR. Long-term ethanol intake causes morphological changes in Schistosoma mansoni adult worms in mice. Exp Parasitol 2019; 203:30-35 (doi: 10.1016/j.exppara.2019.05.010).
  5. Camelo L, Marinho TS, Aguila MB, Souza-Mello V, Barbosa-da-Silva S. Intermittent fasting exerts beneficial metabolic effects on blood pressure and cardiac structure by modulating local renin-angiotensin system in the heart of mice fed high-fat or high-fructose diets. Nutr Res 2019; 63:51-62 (doi: 10.1016/j.nutres.2018.12.005).
  6. Correia BRO, Rachid TL, Glauser, JSO, Martins, FF, Mandarim-de-Lacerda CA, Souza-Mello V. Linagliptin induces browning of the subcutaneous white adipose tissue in diet-induced obese C57BL/6 mice. Endocrine 2019;65:252-262 (doi: 10.1007/s12020-019-01969-y).
  7. Graus-Nunes F, Souza-Mello V. The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis. Biomed Pharmacother 2019; 109:639-645 (doi: 10.1016/j.biopha.2018.10.191).
  8. Graus-Nunes F, Santos F.O., Marinho T.S., Miranda C.S., Barbosa-da-Silva S., Souza-Mello V. Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model. World J Hepatol. 2019; 11(4): 359-369 (doi: 10.4254/wjh.v11.i4.359).
  9. Guimaraes J, Bargut TCL, Mandarim-de-Lacerda CA, Aguila MB. Medium-chain triglyceride reinforce the hepatic damage caused by fructose intake in mice. Prostaglandins, Leukotrienes and Essential Fatty Acids 2019;140:64-71 (doi: 10.1016/j.plefa.2018.11.005).
  10. Karise I, Bargut TC, Del Sol M, Aguila MB, Mandarim-de-Lacerda CA.Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice. Biomed Pharmacother 2019;111;1156-1165 (doi: 10.1016/j.biopha.2019.01.021).
  11. Maia-Ceciliano TC, Dutra RR, Aguila MB, Mandarim-de-Lacerda CA. The deficiency and the supplementation of vitamin D and liver: lessons of chronic fructose-rich diet in mice. J Steroid Biochem Mol Biol 2019;192:105399 (doi: 10.1016/j.jsbmb.2019.105399).
  12. Mandarim-de-Lacerda CA. Breve história da anatomia, com ênfase no sistema cardiovascular. Anais Acad Nac Med 2019;190(2):23-33.
  13. Mandarim-de-Lacerda CA. A brief introduction to the evolutionary anatomy of the skull and face in the genus HomoJ Health Med Sci 2019;5:107-111.
  14. Mandarim-de-Lacerda, CA. Ontogenetic and phylogenetic allometry (bivariate and multivariate) for young morphologists.Int J Morphol 2019;37(2):466-472 (doi: 10.4067/S0717-95022019000200466)
  15. Mandarim-de-Lacerda, CA. Pancreatic islet (of Langerhans) revisited. Histology and Histopathology 2019;34:985-993 (doi: 10.14670/HH-18-118)
  16. Marinho TS, Ornellas F, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Aguila MB. Intermittent fasting beneficial effects on the steatosis and inflammation of the liver in mice fed a high-fat or a high-fructose diet. Nutrition 2019;65:103-112 (doi: 10.1016/j.nut.2019.02.020).
  17. Motta VF, Bargut TL, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Browning is activated in the subcutaneous white adipose tissue of mice metabolically challenged with a high-fructose diet submitted to high-intensity interval training. J Nutr Biochem 2019;70:164-173 (DOI: 10.1016/J.JNUTBIO.2019.05.008).
  18. Oliveira M, Lira R, Freire T, Luna C, Martins M, Almeida A, Carvalho S, Cortez E, Stumbo AC, Thole A, Carvalho L. Bone marrow mononuclear cell transplantation rescues the glomerular filtration barrier and epithelial cellular junctions in a renovascular hypertension model. Exp Physiol 2019; 104(5):740-754 (doi: 10.1113/EP087330).

  19. Petito-da-Silva TI, Souza-Mello V, Barbosa-da-Silva S. Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress. Mol Cell Endocrinol 2019; 498: 110539 (doi: 10.1016/J.MCE.2019.110539).
  20. Pinheiro D, Dias I, Ribeiro Silva K, Stumbo AC, Thole A, Cortez E, de Carvalho L, Weiskirchen R, Carvalho S. Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview. Cells 2019; 8(11):1339. (doi: 10.3390/cells8111339).

  21. Pucu E, Lemos E, Rozental T, Ogrzewalska M, Chame M, Machado-Silva JR, Leles D. Identification of Arthropods By Polymerase Chain Reaction As Probes For Infectious Disease Studies In Experimental Coprolites. J Parasitol 2019; 105(1):133-134 (
  22. Souza-Mello V, Graus-Nunes F, Bringhenti I, Barbosa-da-Silva S. PPARs as potential targets to tackle metabolic impairments: from insulin resistance and inflammation to NAFLD, DM2 and cardiovascular disease. In: Rodrigo B Valenzuela. (Org.). Peroxisome Proliferator-activated receptors (PPARs) Structure, mechanisms of action and role in health and disease. 1ed. Nova Iorque: Nova Science Publishers, Inc., 2019, v. , p. 1-30 (ISBN: 9781536147377).
  23. Tarevnic R, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese.Journal of Developmental Origins of Health and Disease 2018:1-5 (doi: 10.1017/S2040174418001046).


  1. Altomare M, Monte-Alto-Costa A. Manual mobilization of subcutaneous fibrosis in mice. J Manipulative Physiol Ther 2018;41(5):359-362 (doi: 10.1016/j.jmpt.2017.10.011).
  2. Bittencourt-Oliveira F, Teixeira P, Alencar A, Menezes R, Corrêa C, Neves L, Almeida  F, Daipert-Garcia D, Machado-Silva JR, Rodrigues-Silva R. First parasitological, histopathological and molecular characterization of Echinococcus vogeli Rausch and Bernstein, 1972 from Cuniculus paca Linnaeus, 1766 in the Cerrado biome (Mato Grosso do Sul, Brazil). Vet Parasitol 2018; 30: 35-39 (doi: 10.1016/j.vetpar.2017.12.003).
  3. Borges CC, Bringhenti I, Mandarim-da-Lacerda CA, Aguila MB. Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice.Biomed Pharmacotherap 2018;107:878-888 (doi: 10.1016/j.biopha.2018.08.075).
  4. Borges CC, Salles AF, Brighenti I, Mandarim-de-Lacerda CA, Aguila MB. Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice. J Nutr Sci Vitaminol 2018;64(2):106-115 (doi: 10.3177/jnsv.64.106).
  5. Carapeto PV, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Liver metabolism in adult male mice offspring: consequences of a maternal, paternal, or both maternal and paternal high-fructose diet.J Development Origins Health Dis (DOHaD) 2018;9: 450-459(doi: 10.1017/S2040174418000235).
  6. da Silva Neto Trajano LA, Trajano ETL, da Silva Sergio LP, Teixeira AF, Mencalha AL, Stumbo AC, de Souza da Fonseca A. Photobiomodulation effects on mRNA levels from genomic and chromosome stabilization genes in injured muscle. Lasers Med Sci 2018; 33(7):1513-1519 (doi: 10.1007/s10103-018-2510-0).

  7. De Holanda MI, Klumb E, Imada A, Lima LA, Alcântara I, Gregório F, Christiani LF, ; Martins CO, Timoner BE, Motta J, Pozzan R, Pôrto LC. The prevalence of HLA alleles in a lupus nephritis population. Transplant Immunology 2018; 47: 37-43 (doi: 10.1016/j.trim.2018.02.001).
  8. De Holanda MI, Matuck T, De Carvalho DDBM, Domingues EMFL, Curvo R, Glasberg DS, Santos AMG, Borela ÁM, Pôrto LC. Soluble CD30, Acute Rejection, and Graft Survival: Pre- and 6-Month Post-Transplant Determinations-When Is the Best Time to Measure?. Transplantation Proceeding 2018; 50(3):728-36(doi:10.1016/j.transproceed.2018.02.025).
  9. Dias I, Salviano Í, Mencalha A, de Carvalho SN, Thole AA, Carvalho L, Cortez E, Stumbo AC. Neonatal overfeeding impairs differentiation potential of mice subcutaneous adipose mesenchymal stem cells. Stem Cell Rev Rep 2018; 14(4):535-545 (doi: 10.1007/s12015-018-9812-2).

  10. Ornellas F, Bringhenti I, Mattos BA, Mandarim-de-Lacerda CA, Aguila MB. Father’s obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways, especially in adult male mice.Eur J Nutr 2018;57:1901-1912(doi: 10.1007/s00394-017-1473-4).
  11. Rachid TL, Silva-Veiga FM, Graus-Nunes F, Bringhenti I, Mandarim-de-Lacerda CA, Souza-Mello V. Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice.  PLoS ONE 13(1): e0191365 (doi: 10.1371/journal.pone.0191365).
  12. Romana-Souza B, Santos JS, Monte-Alto-Costa A. Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-KB and NOS2 and NRF2 expression. Life Sci 2018; 207:158-165 (doi: 1016/j.lfs.2018.05.057).
  13. Romana-Souza B, Silva-Xavier W., Monte-Alto-Costa. Topical retinol attenuates stress-induced aging signs in human skin , through EGFR activation via EGF, but not ERK and AP-1 activation. Exp Dermatol 2018; (doi: 1111/exd.13675).
  14. Silva-veiga FM, Rachid TL, de Oliveira L, Graus-Nunes F, Mandarim-de-Lacerda CA, Souza-Mello V. GW0742 (PPAR-beta agonist) attenuates hepatic endoplsmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice. Mol Cell Endocrinol 2018; 474:227-237 (doi: 10.1016/j.mce.2018.03.013).
  15. Teixeira PEF, Corrêa CL, Oliveira FB, Alencar ACMB, Neves LBD, Garcia DD, Almeida FB, Pereira LCM, Machado-Silva JR, Rodrigues-Silva R. Occurrence of Capillaria sp. in the liver of sheep (Ovis aries ) in a slaughterhouse in the state of Acre, Brazil. Rev Bras Parasitol Vet 2018; 27(2):226-231 (doi: 10.1590/S1984-296120180030).
  16. Trajano LADSN, Sergio LPDS, Stumbo AC, Mencalha AL, Fonseca ASD. Low power lasers on genomic stability. J Photochem Photobiol B 2018; 180:186-197 (doi:10.1016/j.jphotobiol.2018.02.010).

  17. Trajano LADSN, Trajano ETL, Silva MADS, Stumbo AC, Mencalha AL, Fonseca ASD. Genomic stability and telomere regulation in skeletal muscle tissue. Biomed Pharmacother 2018; 98:907-915 (doi: 10.1016/j.biopha.2018.01.004).


1.Araujo NC, Orlando MMC, Das Neves MB, Mandarim-de-Lacerda CA. Assessment of spleen filtrate function in renal transplant recipients using Technetium-99m stannous colloid liver-spleen scan. Transplant Proceed 2017;49:1301-1306 (doi: 10.1016/j.transproceed.2017.02.061)

2. Araujo NC, Orlando MC, Neves MB, Rioja SS, Lucena SBG, Mandarim-de-Lacerda CA. Howell-Jolly bodies and liver-spleen scanning for assessment of splenic filtrative function yields discordant results in renal transplant recipients. Medicine 2017;96:e9242 (doi: 10.1097/MD.0000000000009242)

3. Bargut TCL, Santos LP, Machado DGL, Aguila MB, Mandarim-de-Lacerda CA. Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): effects in epididymal white adipose tissue of mice fed a high-fructose diet. Prostagland Leukot Essent Fatty Acids 2017;123:14-24 (doi: 10.1016/j.plefa.2017.07.004)

4. Bargut TCL, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA. Browning of white adipose tissue: lessons from experimental models. Horm Mol Biol Clin Inv 2017;31:20160051 (doi: 10.1515/hmbci-2016-0051)

5. Baselga-Escudero L, Souza-Mello V, Pascual-Serrano A, Rachid T, Voci A, Demori I, Grasselli E. Beneficial effects of the mediterranean spices and aromas on non-alcoholic fatty liver disease. Trends Food Sci Technol. 2017; 61: 141-159.

6. Borba Nunes VH, Alcover JA, Silva VL, Cruz PB, Machado-Silva JR, Araujo AJG. Paleoparasitological analysis of the extinct Myotragus balearicus Bate 1909 (Artiodactyla, Caprinae) from Mallorca (Balearic Islands, Western Mediterranean). Parasitol Int 2017; 66: 7-11 (doi: 10.1016/j.parint.2016.11.009)

7. Borges CC, Penna-de-Carvalho A, Medeiros-Junior JL, Aguila MB, Mandarim-de-Lacerda CA. Ovariectomy modifies local renin-angiotensin-aldosterone system gene expressions in the heart of ApoE (-/-) mice. Life Sciences 2017;191:1-8 (doi: 10.1016/j.lfs.2017.10.002)

8. Carnevale S, Malandrini JB, Pantano ML, Soria CC, Rodrigues-Silva R, Machado-silva JR, Velasquez JN, Kamenetsky L. First genetic characterization of Fasciola hepatica in Argentina by nuclear and mitochondrial gene markers. Vet Parasitol 2017; 245: 34-38 (doi: 10.1016/j.vetpar.2017.08.006)

9. Chamma CMO, Bargut TCL, Mandarim-de-Lacerda CA, Aguila MB. A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on markers of hepatic lipogenesis and beta-oxidation. Food & Function 2017;8:778-787 (doi: 10.1039/C6FO01663D)

10. Corrêa FRS, Schanuel FS, Moura-Nunes N, Monte-Alto-Costa A, Daleprane JB. Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB. Biomedicine & Pharmacotherapy, 2017; 86:162-171 (doi: 10.1016/j.biopha.2016.12.018).

11. Dos Santos-Silva MA, Trajano ETL, Schanuel FS, Monte-Alto-Costa, A . Heat delays skin wound healing in mice. Exp Biol Med (Maywood) 2017; 242:258-266 (doi: 10.1177/1535370216675066).

12. Graus-Nunes F, Marinho TS, Barbosa-da-Silva S, Aguila MB, Mandarim-de-Lacerda CA, Souza-Mello V. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Mol Cell Endocrinol 2017;439:54-64 (doi: 10.1016/j.mce.2016.10.021)

13. Graus-Nunes F, Rachid T, De Oliveira Santos F, Barbosa-da-Silva S, Souza-Mello V. AT1 receptor antagonist induces thermogenic beige adipocytes in the inguinal white adipose tissue of obese mice. Endocrine 2017, 55: 786-798.

14. Karise I, Ornellas F, Barbosa-da-Silva S, Matsuura C, Del Sol M, Aguila MB, Mandarim-de-Lacerda CA. Liver and Metformin: lessons of a fructose diet in mice. Biochimie Open 2017;4:19-0 (doi: 10.1016/j.biopen.2017.01.002)

15. Lira R, Oliveira M, Martins M, Silva C, Carvalho S, Stumbo AC, Cortez E, Verdoorn K, Einicker-Lamas M, Thole A, de Carvalho L. Transplantation of bone marrow-derived MSCs improves renal function and Na+K+ -ATPase activity in rats with renovascular hypertension.Cell Tissue Res 2017; 369(2):287-301 (doi: 10.1007/s00441-017-2602-3).

16. Marinho TS, Kawasaki A, Bryntesson M, Souza-Mello V, Barbosa-da-Silva S, Aguila M, Mandarim-de-Lacerda CA. Rosuvastatin limits the activation of hepatic stellate cells in diet-induced obese mice. Hepatol Res 2017;47:928-940 (doi: 10.1111/hepr.12821)

17. Martins FF, Aguila MB, Mandarim-de-Lacerda CA. Impaired steroidogenesis in the testis of leptin-deficient mice (ob/ob -/-). Acta Histochemica 2017;119:508-515 (doi: 10.1016/j.acthis.2017.05.003)

18. Martins FF, Bargut TCL, Aguila MB, Mandarim-de-Lacerda CA. Thermogenesis, fatty acid synthesis and oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann Anat 2017;210:44-51 (doi: 10.1016/j.aanat.2016.11.013)

19. Martins FF, Del Sol M, Aguila MB, Mandarim-de-Lacerda CA. Lean vs. Obese mice: the ventral prostate revisited. Int J Morphol 2017;35:403-412 (doi: 10.4067/S0717-95022017000200003)

20. Medeiros-Lima DJ, Mendes-Ribeiro AC, Brunini TM, Martins MA, Mury WV, Freire RA, Monteiro WD, Farinatti PT, Matsuura C. Erythrocyte nitric oxide availability and oxidative stress following exercise. Clin Hemorheol Microcirc 2017;65:219-228. doi: 10.3233/CH-16162.

21. Motta VF, Bargut TL, Aguila MB, Mandarim-de-Lacerda CA. Treating fructose-induced metabolic changes in mice with high-intensity interval training: insights in the liver, white adipose tissue and skeletal muscle. J Appl Physiol 2017;123:699-709 (doi: 10.1152/japplphysiol.00154.2017)

22. Neves LB, Teixeira PEF, Silva S, de Oliveira FB, Garcia DD, Almeida FB, Rodrigues-Silva R,  Machado-Silva, JR. First molecular identification of Echinococcus vogeli and Echinococcus granulosus (sensu stricto) G1 revealed in feces of domestic dogs (Canis familiaris) from Acre, Brazil. Parasites & Vectors 2017; 10: 28 (doi: 10.1186/s13071-016-1952-0)

23. Oliveira GS, Neves VS, Rangel S, Souza-Mello V, Barbosa-da-Silva S. High-intensity interval training has beneficial effects on cardiac remodeling through local renin-angiotensin system modulation in mice fed high-fat or high-fructose diets. Life Sci 2017; 189: 8-17.

24. Ornellas F, Carapeto PV, Mandarim-de-Lacerda CA, Aguila MB. Obese fathers lead to an altered metabolism and obesity in their children in adulthood: a review of experimental and human studies. J Pediat 2017;93:551-559 (doi: 10.1016/j.ped.2017.02.004).

24. Pinheiro D, Leirós L, Dáu JBT, Stumbo AC, Thole AA, Cortez EAC, Mandarim-de-Lacerda CA, Carvalho L, Carvalho SN. Cytokines, hepatic cell profiling and cell interactions during bone marrow cell therapy for liver fibrosis in cholestatic mice. PLoS One 2017; 12(11):e0187970 (doi: 10.1371/journal.pone.0187970).

25. Silva CO,  Monte-Alto-Costa A, Renovato M, Nascimento FJV, Lagente V, Porto LC, Victoni T. Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo. Int J Mol Sci 201; 18:E1940 (doi: 10.3390/ijms18091940).

26. Souza JGR, Lopes Torres EJ, Garcia JS, Gomes APN, Rodrigues-Silva R,   Maldonado, A, Machado-Silva, JR. Light and scanning electron microscopy study of in vitro effects of artesunate in newly excysted metacercariae of Echinostoma paraensei (Trematoda: Digenea). Exp Parasitol 2017; 174: 10-16 (doi: 10.1016/j.exppara.2017.01.003)

27. Souza-Mello V. Hepatic structural enhancement and insulin resistance amelioration due to AT1 receptor blockade. World J Hepatol 2017; 9:74-79.

28. Veiga FMS, Graus-Nunes F, Rachid TL, Barreto AB, Mandarim-de-Lacerda CA, Souza-Mello V. Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): Hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice. Biochimie 2017;140:106-116 (doi: 10.1016/j.biochi.2017.07.003).

29. Verdoorn KS, Matsuura C, Borges JP. Exercise for cardiac health and regeneration: killing two birds with one stone. Ann Transl Med 2017;5(Suppl 1):S13. doi: 10.21037/atm.2017.03.10.

30. Vianna ARCB, Aguila MB, Mandarim-de-Lacerda CA. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metabol Brain Dis 2017;32:1735-1745 (doi: 10.1007/s11011-017-0059-4).